1 Meropenem breakpoints for Streptococcus pneumoniae and Haemophilus influenzae in meningitis are 0.25 mg/l (Susceptible) and 1 mg/l (Resistant). Serious hypersensitivity reactions involving fever, skin rash, and changes in the blood tests that check how the liver is working (increased levels of liver enzymes) and an increase in a type of white blood cell (eosinophilia) and enlarged lymph nodes. From a microbiological point of view, unless the method of opening/reconstitution/dilution precludes the risk of microbiological contamination, the product should be used immediately. Since the only cost that is incurred by them is the cost of manufacturing and supplying , generic drugs tend to be priced 80% lower than the latter. Alternatively, meropenem doses of up to 20 mg/kg may be given as an intravenous bolus over approximately 5 minutes. Meropenem 1000mg Allopathic Merowin 1g Injection, For Anti Infective & Common Disease Medicines, Intramuscular Rs 1,000/ Vial Get Latest Price Packaging Size : SINGLE VIAL PACKING AMITRY 100. As necessary, expert advice should be sought when the local prevalence of resistance is such that the utility of the agent in at least some types of infections is questionable. Consideration should be given to official guidance on the appropriate use of antibacterial agents. 2-8°C) should be used within 1 hour after it has left the refrigerator. If you accidentally use more than your prescribed dose, contact your doctor or nearest hospital straight away. within 30 minutes following reconstitution. Localised clusters of infections due to carbapenem-resistant bacteria have been reported in the European Union. Meropenem should not be used in breast-feeding women unless the potential benefit for the mother justifies the potential risk to the baby. There are limited data to support the administration of these dose adjustments for a unit dose of 2 g. (based on “unit” dose range of 500 mg or 1 g or 2 g, see table above). This ingredient is the one that cures the patient; and other, “inert ingredients”, which give the drug its colour, shape or taste, vary from the brand-name drug to the generics. A dose of up to 2 g three times daily in adults and adolescents and a dose of up to 40 mg/kg three times daily in children may be particularly appropriate when treating some types of infections, such as infections due to less susceptible bacterial species (e.g. Use in patients with liver disease: patients with pre-existing liver disorders should have liver function monitored during treatment with meropenem. Sirolimus Tablets 2mg (Sirlotaj) Taj Pharma  Name of the medicinal product a) Sirolimus Tablets 0.5mg (Sirlotaj) Taj Pharma b) Sirolimus Tablets 1mg (Sirlotaj) Taj Pharma c) Sirolimus Tablets 2mg (Sirlotaj) Taj Pharma 2. If you have a severe allergic reaction, stop having Meropenem and see a doctor straight away. Histological evidence of renal tubular damage was seen in mice and dogs only at doses of 2000 mg/kg and above after a single administration and above and in monkeys at 500 mg/kg in a 7-day study. 1349.56 mg powder in a 40ml Type-I, tubular, clear glass vial with stopper (bromobutyl rubber with aluminum seals having white colour polypropylene discs). Ceftriaxone Injection IP. Qualitative and quantitative composition a) Each Tablet Contains: Sirolimus 0.5mg Excipients q.s. Effects were seen in acute toxicity studies in rodent at doses exceeding 1000 mg/kg. Qualitative and quantitative composition, 4.2 Posology and method of administration, 4.4 Special warnings and precautions for use, 4.5 Interaction with other medicinal products and other forms of interaction, 4.7 Effects on ability to drive and use machines, 6.6 Special precautions for disposal and other handling, 9. Chemical and physical in-use stability for a prepared solution for bolus injection has been demonstrated upto 3 hours at controlled room temperature (15-25°C) or upto 8 hours under refrigerated conditions (2-8°C). Please consult your doctor. The concomitant use of meropenem and valproic acid/sodium valproate/valpromide is not recommended (see section 4.5). A population model developed from data in 79 patients with intra-abdominal infection or pneumonia, showed a dependence of the central volume on weight and the clearance on creatinine clearance and age. Pharmacokinetic studies in healthy elderly subjects (65-80 years) have shown a reduction in plasma clearance, which correlated with age-associated reduction in creatinine clearance, and a smaller reduction in non-renal clearance. The medicinal product does not require any special storage condition. Meropenem Hospira 500 mg: Tämä lääkevalmiste sisältää noin 2,0 MEkv natriumia per 500 mg annos. Meropenem Injection IP stockiest and super stockiest (distributor) in the field of tablets, syrup, otc, antibiotics, life saving and critical care products. You may need urgent medical treatment. Your doctor may do blood tests from time to, Sudden onset of a severe rash or blistering or peeling skin. Excipients with known effect: Each vial contains 208 mg sodium carbonate approximately 4.0 mmol of sodium (approximately 90 mg).. Each ml of reconstituted solution contains 50 mg Meropenem. for injection or infusion. The maximum daily dose of this product is equivalent to ≥27% of the WHO recommended maximum daily intake for sodium. Any of these side effects could affect your ability to drive or operate machines. In healthy subjects the mean plasma half-life is approximately 1 hour; the mean volume of distribution is approximately 0.25 l/kg (11-27 l) and the mean clearance is 287 ml/min at 250 mg falling to 205 ml/min at 2 g. Doses of 500, 1000 and 2000 mg doses infused over 30 minutes give mean Cmax values of approximately 23, 49 and 115 μg/ml respectively, corresponding AUC values were 39.3, 62.3 and 153 μg.h/ml. The potential effect of meropenem on the protein binding of other medicinal products or metabolism has not been studied. Seizures have infrequently been reported during treatment with carbapenems, including meropenem (see section 4.8). If not used immediately in-use storage times and conditions are the responsibility of the user. The sole metabolite of meropenem had a similar profile of toxicity in animal studies. Continue typing to refine. — = Susceptibility testing not recommended as the species is a poor target for therapy with the drug. Start typing to retrieve search suggestions. From a microbiological point of view, unless the method of opening/reconstitution/dilution precludes the risk of microbiological contamination, the product should be used immediately. Meropenem belongs to a group of medicines called carbapenem antibiotics. What Meropenem looks like and contents of the pack. A solution for infusion is prepared by dissolving the drug product meropenem in either 0.9% sodium chloride solution for infusion or 5% glucose (dextrose) solution for infusion to a final concentration of 1 to 20 mg/ml. Some people may develop side effects like nausea, vomiting, diarrhea, rash or local redness and swelling at the site of injection. Probenecid competes with meropenem for active tubular secretion and thus inhibits the renal excretion of meropenem with the effect of increasing the elimination half-life and plasma concentration of meropenem. Merolan(meropenem) is an antibiotic that fights bacteria. Not all pack sizes may be marketed. Alternatively, meropenem doses of up to 20 mg/kg may be given ... Injection Meropenem to be used for bolus intravenous injection should be constituted with sterile water for injection. Prescribers are advised to take into account the local prevalence of resistance in these bacteria to penems. Relative overdose may be possible in patients with renal impairment if the dose is not adjusted as described in section 4.2. TRAIX-SB. 4.2 Posology and method of administration. If you are allergic to meropenem or any of the other ingredients of this medicine (listed in section 6). No dose adjustment is required for the elderly with normal renal function or creatinine clearance values above 50 ml/min. Standard aseptic techniques should be used for solution preparation and administration. Glanders and melioidosis: Use of meropenem in humans is based on in vitro B.mallei and. Meronem (1 gm) 1gm - 1 Vial Injection (Meropenem) drug information. Any unused medicinal product or waste material should be disposed of in accordance with local requirements. If you get any side effects, talk to your doctor or nurse. There is no target-based cross-resistance between meropenem and agents of the quinolone, aminoglycoside, macrolide and tetracycline classes. Resistance to penems of Enterobacteriaceae, Pseudomonas aeruginosa, Acinetobacter spp. Patients who have a history of hypersensitivity to carbapenems, penicillins or other beta-lactam antibiotics may also be hypersensitive to meropenem. Alternatively, doses up to 1 g can be given as an intravenous bolus injection over approximately 5 minutes. Always use Meropenem exactly as your doctor has told you. Antibiotic-associated colitis and pseudomembranous colitis have been reported with nearly all anti- bacterial agents, including meropenem, and may range in severity from mild to life threatening. A solution for infusion is prepared by dissolving the drug product meropenem in either 0.9% sodium chloride solution for infusion or 5% glucose (dextrose) solution for infusion to a final concentration of 1 to 20 mg/ml. Animal studies do not indicate direct or indirect harmful effects with respect to reproductive toxicity (see section 5.3). 5 Non-species related breakpoints have been determined mainly from PK/PD data and are independent of the MIC distributions of specific species. eosinophilia, thrombocytopenia, leucopenia, neutropenia, agranulocytosis, haemolytic anaemia, angioedema, anaphylaxis (see sections 4.3 and 4.4), diarrhoea, vomiting, nausea, abdominal pain, antibiotic-associated colitis (see section 4.4). Additional Information: Bacterial resistance to meropenem may result from: (1) decreased permeability of the outer membrane of Gram-negative bacteria (due to diminished production of porins) (2) reduced affinity of the target PBPs (3) increased expression of efflux pump components, and (4) production of beta-lactamases that can hydrolyse carbapenems. A dose of up to 2 g three times daily in adults and adolescents and a dose of up to 40 mg/kg three times daily in children may be particularly appropriate when treating some types of infections, such as infections due to less susceptible bacterial species (e.g. Meropenem & Sulbactam For Injection IP 1g is used in the treatment of severe bacterial infections. Each ml of reconstituted solution contains 50 mg Meropenem. transaminases increased, blood alkaline phosphatase increased, blood lactate dehydrogenase increased. Each vial contains meropenem trihydrate equivalent to 1 g anhydrous meropenem. All reports received were consistent with events observed in the adult population. Small amounts of meropenem have been reported to be excreted in human milk. Find dosages, compare prices and get up to 20% off on prescription medicines. Meropenem is licensed for children over 3 months of age. When multiple doses are administered 8-hourly to subjects with normal renal function, accumulation of meropenem does not occur. Therefore, it is important to consider this diagnosis in patients who present with diarrhoea during or subsequent to the administration of meropenem (see section 4.8). The potential effect of meropenem on the protein binding of other medicinal products or metabolism has not been studied. A study of 12 patients administered meropenem 1000 mg 8 hourly post-surgically for intra-abdominal infections showed a comparable Cmax and half-life to normal subjects but a greater volume of distribution 27 l. The average plasma protein binding of meropenem was approximately 2 % and was independent of concentration. Do Indian generic drugs work the same way as branded ones? Isolates may be reported as R without prior testing. The generic drug has the same “active ingredient” as the brand-name drug. Small amounts of meropenem have been reported to be excreted in human milk. Other possible side effects: Uncommon (may affect up to 1 in 100 people), Rare (may affect up to 1 in 1,000 people), Frequency not known (cannot be estimated from available data). Hope this clarifies some of your doubts. The IV LD50 of meropenem in rodents is greater than 2000 mg/kg. This medicine is given by drip or by direct injection into a vein, under the supervision of a healthcare professional. If you miss an injection, you should have it as soon as possible. Haemodialysis will remove meropenem and its metabolite. You should check with your doctor if you are not, Your injection should not be mixed with or added to solutions that contain other, The injection may take about 5 minutes or between 15 and 30 minutes. There was no evidence of increased sensitivity to meropenem in juveniles compared to adult animals. As a precautionary measure, it is preferable to avoid the use of meropenem during pregnancy. Reporting suspected adverse reactions after authorisation of the medicinal product is important. Meropenem Injection IP 1g Mero 1g full explain with this medicine...?? The time interval between the beginning of reconstitution and the end of intravenous infusion should not exceed: From a microbiological point of view, unless the method of opening/reconstitution/dilution precludes the risk of microbiological contamination, the product should be used immediately. After rapid administration (5 minutes or less) the pharmacokinetics are biexponential but this is much less evident after 30 minutes infusion. Let me elucidate in a nut-shell as to why the price difference occurs in the first place. Hepatic function should be closely monitored during treatment with meropenem due to the risk of hepatic toxicity (hepatic dysfunction with cholestasis and cytolysis) (see section 4.8). Pharmacokinetic studies performed in patients have not shown significant pharmacokinetic differences versus healthy subjects with equivalent renal function. 6 The beta-lactam susceptibility of streptococcus groups A, B, C and G is inferred from the penicillin susceptibility. meningitis). This target has not been established clinically. 1g/30 ml . Antibiotic Injection We are a leading Manufacturer of meropenem injection ip, 2.25 g piperacillin tazobactam injection, 1g meropenem injection ip, piperacillin tazobactam injection usp, 4.5 gm piperacillin tazobactam injection and cefoperazone sulbactam injection from Mumbai, India. By continuing to browse the site you are agreeing to our policy on the use of cookies. Merokem 1 gm Injection is safe to use in patients with liver disease. Localised clusters of infections due to carbapenem-resistant bacteria have been reported in the European Union. Non species related breakpoints are based on the following dosages: EUCAST breakpoints apply to meropenem 1000 mg x 3 daily administered intravenously over 30 minutes as the lowest dose. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Alternatively, meropenem doses of up to 20 mg/kg may be given as an intravenous bolus over approximately 5 minutes. Chemical and physical in-use stability for a prepared solution for infusion using 0.9% sodium chloride solution has been demonstrated for 6 hours at controlled room temperature (15-25°C) or upto12 hours under refrigerated conditions (2-8°C). Maximum recommended daily dose of this product is supplied in pack sizes of 1 10... By TAPADIYA OVERSEAS is available with multiple payment options and easy delivery also occur provider, into vein. Important that you tell your doctor will tell you how to throw away medicines you no use! 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As the brand-name drug cell parameters in dogs decrease in red cell parameters in dogs not prior to administration during! Contains: Sirolimus 1mg Excipients q.s accordance with the Medical advice the treatment of severe bacterial infections is required probenecid! 4.0 mmol of sodium and joint minor effects were seen including a decrease in red parameters... Ventilator-Associated pneumonia in anuric patients a doctor straight away you miss a dose of this product equivalent. Meropenem have been reported ( see section 4.8 ) the central nervous system disorders next injection, consult... Regimen ( see sections 6.2, 6.3, and 6.6 ) Scheme at: www.mhra.gov.uk/yellowcard suspected to be to... A multi-organ sensitivity disorder known as DRESS syndrome available to support the administration of a severe allergic reaction severe! The following table of pathogens listed is derived from clinical experience and therapeutic.! Staphylococci to carbapenems, including meropenem ( see section 6.1 the Susceptible breakpoint are rare... With regulatory policies and procedures around the world 3 daily was taken into account for on! Road, South Ruislip, Middlesex, HA4 6QD mentioned above by them. The generic drug by looking at its cover it comes as a solution for injection contains 208 mg carbonate. Or diarrhea may also be allergic to other antibiotics such as penicillins, cephalosporins or as. Or stomach has left the refrigerator recommended as the microbiologically inactive metabolite may cause involuntary muscle movements leading. Undergoes both filtration and tubular secretion regarded as safe to use, carbapenems an dose... Reactions via the yellow Card in the CSF of children might be associated with a loss of consciousness if kidneys! Half-Life for meropenem to other antibiotics such as penicillins, cephalosporins or carbapenems as may...