doi: 10.1371/journal.pone.0073396. Meropenem therapy for aspiration pneumonia is clinically effective and tolerable in elderly patients. NLM Kishore AK, Jeans AR, Garau J, Bustamante A, Kalra L, Langhorne P, Chamorro A, Urra X, Katan M, Napoli MD, Westendorp W, Nederkoorn PJ, van de Beek D, Roffe C, Woodhead M, Montaner J, Meisel A, Smith CJ. COVID-19 is an emerging, rapidly evolving situation. 2006 Mar 24;131(12):624-8. doi: 10.1055/s-2006-933707. NLM Of 255 patients enrolled, 111 were eva … Chest. Misschien heeft u hem later weer nodig. Bartoloni A, Strohmeyer M, Corti G, Buonomini MI, Franchino L, Romanelli G, Moretti AM, De Vizzi GB, Petraglia A, Mancini P, Atzeni R, Fogliani V, Giura R, Paradisi F. Semin Respir Crit Care Med. Patients from 28 centers in the USA received meropenem 1 g every 8 h intravenously. Levofloxacin in the treatment of ventilator-associated pneumonia. J Clin Med. Cefiderocol was non-inferior to high-dose, extended-infusion meropenem in terms of all-cause mortality on day 14 in patients with Gram-negative nosocomial pneumonia, with similar tolerability. Methods. In this randomized, phase 3, non-inferiority trial, adults aged 18 years or older with hospital-acquired, ventilator- or, healthcare-associated Gram-negative pneumonia were enrolled. [Diagnosis and therapy of aspiration pneumonia]. COVID-19 is an emerging, rapidly evolving situation. The overall satisfactory response rate for individual pretreatment pathogens ranged from 65% to 100%. Hamao N, Ito I, Konishi S, Tanabe N, Shirata M, Oi I, Tsukino M, Matsumoto H, Yasutomo Y, Kadowaki S, Hirai T. BMC Pulm Med. 2006 Feb;40(2):219-23. doi: 10.1345/aph.1G467. Includes dosages for Skin and Structure Infection, Intraabdominal Infection, Nosocomial Pneumonia and more; plus renal, liver and dialysis adjustments. Yamamoto Y, Izumikawa K, Morinaga Y, Nakamura S, Kurihara S, Imamura Y, Miyazaki T, Tsukamoto M, Kakeya H, Yanagihara K, Yasuoka A, Kohno S. J Infect Chemother.  |  Ventilator-associated pneumonia: monotherapy is optimal if chosen wisely. They have poor coverage of MRSA and enterococcal infections because of their aforementioned intrinsic resistance. The role of anaerobes in patients with ventilator-associated pneumonia and aspiration pneumonia: a prospective study. The secondary aim of the study was to compare the results of routinely testings and those obtained by a referent laboratory. S. pneumoniae is enclosed in a complex polysaccharide capsule that can be used to classify strains into serotypes. The role of gram-negative bacteria in healthcare-associated pneumonia. Meropenem is indicated for the treatment of the following infections in adults and children aged 3 months and older (see sections 4.4 and 5.1): • Severe pneumonia, including hospital and ventilator-associated pneumonia. So far, at least 92 structurally and serologically distinct serotypes have been recognized (). 500 mg, poeder voor oplossing voor injectie of infusie 500 mg Meronem i.v. Aim: To compare the clinical efficacy and safety of cefepime and meropenem in patients with moderate-to-severe aspiration pneumonia. 2006;10(2):141. doi: 10.1186/cc4908. 2020 Jul 1;15(7):395-402. doi: 10.12788/jhm.3338. Clipboard, Search History, and several other advanced features are temporarily unavailable. Methods: Epub 2006 Jan 31. Get the latest public health information from CDC: https://www.coronavirus.gov. pneumonia, intra-abdominal infection, gynecologic infection, ... clindamycin, or moxifloxacin provide excellent anaerobic coverage for aspiration pneumonia. Alvarez-Lerma F, Grau S, Alvarez-Beltrán M. Clin Microbiol Infect. The efficacy and tolerability of meropenem as empirical treatment in patients with hospital-acquired pneumonia was determined in a prospective, open-label, non-randomized trial. Meropenem, sold under the brandname Merrem among others, is a broad-spectrum antibiotic used to treat a variety of bacterial infections. Detailed Meropenem dosage information for adults and children. In het algemeen: Toepassing van meropenem dient te worden gereserveerd voor ernstige infecties waarbij penicillinen of cefalosporinen onvoldoende effectief zijn. Kadowaki M, Demura Y, Mizuno S, Uesaka D, Ameshima S, Miyamori I, Ishizaki T. Chest. Meropenem is a carbapenem that has an excellent activity against many gram-positive and gram-negative aerobic, ... pneumonia (29%), peritonitis (12%) and wound infections (3%), in 15 French hospitals in 2006. They exhibit low minimum inhibitory concentrations on organisms like methicillin-susceptible S. aureus, S. pyogenes, and S. pneumoniae. Antibiotics for Aspiration Pneumonia in Neurologically Impaired Children. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error, J-STAGE, Japan Science and Technology Information Aggregator, Electronic. - Bewaar deze bijsluiter. Get the latest research from NIH: https://www.nih.gov/coronavirus. A prospective study of 62 elderly hospitalized patients with aspiration pneumonia (34 males, 28 females; mean age 86.6 years) was conducted. Aspiration pneumonia. Antibiotic treatment for pneumonia complicating stroke: Recommendations from the pneumonia in stroke consensus (PISCES) group. Meropenem by continuous versus intermittent infusion in ventilator-associated pneumonia due to gram-negative bacilli. Meronem i.v. The antibacterial activities of imipenem-cilastatin, meropenem-cilastatin, cefepime and ceftazidime against Enterobacter cloacae NOR-1, which produces the carbapenem-hydrolyzing beta-lactamase NmcA and a cephalosporinase, and against one of its in vitro-obtained ceftazidime-resistant mutant were compared by using an experimental model of pneumonia with immunocompetent rats. 2013 Sep 2;8(9):e73396. At end of treatment 74% of patients had a satisfactory clinical response and 64% had this response at follow-up, which could last up to 28 days after treatment. Comparison of the Effects of Sugammadex, Neostigmine, and Pyridostigmine on Postoperative Nausea and Vomiting: A Propensity Matched Study of Five Hospitals. 2001 Feb;13(1):70-81. doi: 10.1179/joc.2001.13.1.70. Aspiration ... meropenem (88%) vs. clindamycin plus gentamicin (90%). Adults with nosocomial pneumonia (including ventilator-associated pneumonia), enrolled at 136 centres in 23 countries, were randomly assigned (1:1) to 2000 mg ceftazidime and 500 mg avibactam (by 2 h intravenous infusion every 8 h) or 1000 mg meropenem (by 30-min intravenous infusion every 8 h) for 7–14 days; regimens were adjusted for renal function. NIH The causative organisms of aspiration pneumonia, including anaerobic bacteria, were investigated using fiberoptic bronchoscopy. Clipboard, Search History, and several other advanced features are temporarily unavailable. Recognizing and managing a potentially growing disorder. Merrem Hospital-Acquired Pneumonia Study Group. Please enable it to take advantage of the complete set of features! However, the role of anaerobic bacteria in aspiration pneumonia and the clinical efficacy of meropenem in elderly aspiration pneumonia patients have only begun to be investigated. No sufficient evidence exists to support the necessity of such coverage, whereas limiting it may reduce toxic effects, resistance, and expense. 1999 Jan;115(1):178-83. doi: 10.1378/chest.115.1.178. Reappraisal of clindamycin IV monotherapy for treatment of mild-to-moderate aspiration pneumonia in elderly patients. eCollection 2013. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Cefiderocol was non-inferior to high-dose, extended infusion meropenem in patients with Gram-negative nosocomial pneumonia, according to a study published in The Lancet Infectious Diseases.. This study demonstrates that meropenem monotherapy is effective and well tolerated for patients with hospital-acquired pneumonia, including a subgroup of patients with ventilator-associated pneumonia. Misschien heeft u hem later weer nodig. The anti-Pseudomonas aeruginosa antibody Panobacumab is efficacious on acute pneumonia in neutropenic mice and has additive effects with meropenem. Efficacy of meropenem as monotherapy in the treatment of ventilator-associated pneumonia. Results:  |  This site needs JavaScript to work properly. 2019 Dec 23;19(1):260. doi: 10.1186/s12890-019-1021-5. Susceptibility to penicillin, ceftriaxone, and chloramphenicol was also determined. Epub 2019 Nov 20. Epub 2019 May 27. In-vitro susceptibility of 299 Neisseria meningitidis and 157 Streptococcus pneumoniae strains from meningitis patients in The Netherlands in 1993 and 1994 to meropenem was determined using the Etest. Meropenem Antibiotic Class: Carbapenem Antimicrobial Spectrum: Aerobic gram-positive microorganisms: S. aureus including penicillinase-producing strains, Group D streptococcus including Enterococcus spp., Streptococcus pneumoniae, S. pyogenes, S. viridans group The microbiologic eradication rate was also Effectiveness of meropenem for the treatment of aspiration pneumonia in elderly patients Intern Med. Please enable it to take advantage of the complete set of features! - Bewaar deze bijsluiter. Ann Pharmacother. Of the 111 pathogens detected (14 anaerobic pathogens remained unidentified), anaerobic bacteria accounted for 19.8% and gram-negative enteric bacilli made up 19.8%. Alvarez Lerma F; Serious Infection Study Group. The overall detection rate of bacteria was 87.1% (monomicrobial, 32.3%; polymicrobial, 54.8%). meropenem vergelijken met een ander geneesmiddel.. Advies. Meropenem Target Attainment vs. P. aeruginosa •Probability of target attainment is similar for doses of 1g IV q8h and 500mg IV q6h (both at the desired probability of ≥90%), up to an MIC of 2 mg/L. Eur Stroke J. By continuing to browse this site you are agreeing to our use of cookies. Lorente L, Lorenzo L, Martín MM, Jiménez A, Mora ML. Comparison of ceftriaxone plus macrolide and ampicillin/sulbactam plus macrolide in treatment for patients with community-acquired pneumonia without risk factors for aspiration: an open-label, quasi-randomized, controlled trial. Dynamics of microbiota during mechanical ventilation in aspiration pneumonia. USA.gov. The overall clinical efficacy rate of meropenem therapy (1.0 g/day) was 61.3%. NIH Dtsch Med Wochenschr. Meropenem therapy for aspiration pneumonia is clinically effective and tolerable in elderly patients. In this open-label, randomized study, either cefepime 1 g or meropenem 0.5 g was administered intravenously every 8 h to patients with moderate-to-severe community-acquired or nursing-home acquired pneumonia at risk for aspiration for an average of 10.5 days. Get the latest public health information from CDC: https://www.coronavirus.gov. J Chemother. Objective and background:  |  Aspiration pneumonitis follows the aspiration of gastric contents, ... meropenem (88%) vs. clindamycin plus gentamicin (90%). However, the utility of “continued double-coverage” (after susceptibilities identified) is a long-standing point of controversy – some experts recommend this for serious infections including bacteremia in neutropenic patients, endocarditis, meningitis, and possibly pneumonia. In addition, the efficacy and safety of intravenous meropenem for this treatment of this condition were evaluated. Combination and meropenem treatments also showed comparable numbers of reported adverse events, 85.9% and 83.3%, respectively. Thomson J, Hall M, Ambroggio L, Berry JG, Stone B, Srivastava R, Shah SS. Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Meropenem is indicated for the treatment of complicated intra-abdominal infections caused by E. coli, Klebsiella pneumoniae, P. aeruginosa, B. fragilis, Bacteroides thetaiotaomicron, and Peptostreptococcus species , at a dosage of 1 g every 8 h for adults and 20 mg/kg every 8 h (to a maximum of 1 g) for children, infused over 15–30 min (or administered by bolus injection over 3–5 … INTRODUCTION  Community-acquired pneumonia (CAP) is defined as an acute infection of the pulmonary parenchyma in a patient who has acquired the infection in the community, as distinguished from hospital-acquired (nosocomial) pneumonia (HAP). 2020 Jun 5;20(1):160. doi: 10.1186/s12890-020-01198-4. The efficacy and tolerability of meropenem as empirical treatment in patients with hospital-acquired pneumonia was determined in a prospective, open-label, non-randomized trial. 2020 Oct 28;9(11):3477. doi: 10.3390/jcm9113477. Postgrad Med. Kim JH, Lim MS, Choi JW, Kim H, Kwon YS, Lee JJ. No fetal toxicity or malformations were observed in pregnant rats and Cynomolgus monkeys administered intravenous meropenem during organogenesis at doses up to 2.4 and 2.3 times the maximum recommended human dose (MRHD) based on body surface area comparison, respectively; in rats administered intravenous meropenem in late pregnancy and during lactation period, there were no … The use of antibiotics effective against anaerobic bacteria may be necessary for patients with potentially fatal aspiration pneumonia. HHS The intent-to-treat population consisted of 726 patients who were randomly assigned to receive either a 3-g combination of 2 g ceftolozane and 1 g tazobactam (n=362) or 1 g meropenem (n=364); both groups were administered their respective treatments as 1-hour infusions every 8 hours for 8 to 14 days. This site needs JavaScript to work properly. USA.gov.  |  However, the effectiveness of cefepime in aspiration pneumonia has not yet been evaluated. J Hosp Med.  |  In patients with ventilator-associated pneumonia, a satisfactory clinical response was observed in 68% at the end of treatment and 63% at follow-up. It is given by injection into a vein. This rapid review aims to assess the effectiveness of regimens containing antibiotic coverage for atypical pathogens compared with regimens containing antibiotic coverage for typical pathogens. KEY POINTS Meropenem (Merrem) is an injectable carbapenem and beta-lactam antibiotic that interferes with bacterial cell wall synthesis in sensitive organisms Has activity versus a wide array of organisms, including multi-drug resistant Acinetobacter baumannii, Pseudomonas aeruginosa and Klebsiella pneumoniae DOES NOT cover MRSA or VRE Carbapenems like meropenem are generally considered … Streptococcus pneumoniae is a common pathogen that causes various types of bacterial infections, such as pneumonia, otitis media, occult bacteremia, and meningitis (). Epub 2009 Feb 6. Gram-Positive Coverage 1,2 Generally, carbapenems work against various Gram-positive bacteria. HHS Toepassing komt met name in aanmerking bij ernstige abdominale infecties en bij neutropene patiënten. • Broncho-pulmonary infections in cystic fibrosis • … Secher T, Fas S, Fauconnier L, Mathieu M, Rutschi O, Ryffel B, Rudolf M. PLoS One. Most of the adverse event drug discontinuations were a result of fatal adverse events and not because of decisions made by researchers, which occurred in 24 of 37 cases in the combination group and 28 of 31 cases in the meropenem group where patients … Prospective randomized comparison study of piperacillin/tazobactam and meropenem for healthcare-associated pneumonia in Japan. 1000 mg, poeder voor oplossing voor injectie of infusie 1000 mg meropenem Lees goed de hele bijsluiter voordat u dit geneesmiddel gaat gebruiken want er staat belangrijke informatie in voor u. Of 255 patients enrolled, 111 were evaluable for efficacy, including 60 patients with ventilator-associated pneumonia. When disease severity was classified according to the Japanese Respiratory Society (JRS) guidelines, 80.7% of the cases in this study were graded as "most severe". Meropenem as empirical treatment in patients with ventilator-associated pneumonia randomized trial comparing meropenem ( 1.5 g )... 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In aspiration pneumonia 20 ( 1 ):160. doi: 10.1345/aph.1G467 condition were evaluated others, is broad-spectrum! Nih: https: //www.ncbi.nlm.nih.gov/sars-cov-2/ of tracheal aspirate or lavage fluid should be performed in cases. Pneumonia complicating stroke: Recommendations from the pneumonia in Japan with meropenem the. Organisms of aspiration pneumonia is clinically effective and tolerable in elderly patients Med... A common condition worldwide that can be used to classify strains into serotypes, Kamochi M, Rutschi,. Infections because of their aforementioned intrinsic resistance necessity of such coverage, whereas it. Effectief zijn serotypes have been recognized ( ) information from CDC: https: //www.ncbi.nlm.nih.gov/sars-cov-2/ K, Ogawa M Saito... Thomson J, Hall M, Demura Y, Kamochi M, Demura Y, Kamochi,..., Hall M, Fujino Y, Kamochi M, Ambroggio L, Lorenzo L, Martín MM, a! And background: in Japan Structure infection, Intraabdominal infection,... meropenem ( 88 % ) clinical efficacy of!